Deplin 15 is a prescription-strength medical food formulated to address folate deficiency in patients with major depressive disorder. Unlike standard folic acid supplements, it contains L-methylfolate—the bioactive form of folate that crosses the blood-brain barrier without requiring metabolic conversion. This active ingredient supports the synthesis of critical neurotransmitters including serotonin, norepinephrine, and dopamine, which regulate mood and emotional well-being. Designed for clinical dietary management, Deplin 15 provides immediate nutritional support for patients seeking evidence-based adjunctive care.